GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2273 | 1 | rs2273 | chr4:76889388 | NAAA | chr4:76831809-76862166:- | 0.37 | 6.07 | 3.05E-9 | Longevity |
| BLCA | cis | rs11622475 | 1 | rs2273610 | chr14:104387642 | TDRD9 | chr14:104394817-104519002:+ | 0.35 | 5.6 | 4.0E-8 | Bipolar disorder |
| BLCA | cis | rs2275426 | 1 | rs2275426 | chr1:46487552 | CCDC163P | chr1:45960581-45965646:- | -0.34 | -6.43 | 3.89E-10 | Body mass index |
| BLCA | cis | rs4372836 | 1 | rs2276547 | chr2:28975107 | TRMT61B | chr2:29072690-29093175:- | -0.3 | -5.31 | 1.89E-7 | Body mass index |
| BLCA | cis | rs2277862 | 1 | rs2277862 | chr20:34152782 | CPNE1 | chr20:34213968-34262539:- | -0.54 | -6.68 | 8.34E-11 | Cholesterol, total |
| BLCA | cis | rs2241437 | 1 | rs2278086 | chr2:86281905 | LOC90784 | chr2:86247339-86250991:- | -0.46 | -4.77 | 2.59E-6 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| BLCA | cis | rs9876781 | 1 | rs2279077 | chr3:48474249 | TREX1 | chr3:48501186-48509043:+ | -0.19 | -3.86 | 0.000134 | Longevity |
| BLCA | cis | rs12220238 | 1 | rs2279648 | chr10:75867193 | ADK | chr10:75910965-76469059:+ | 0.28 | 4.03 | 6.64E-5 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs2280018 | 1 | rs2280017 | chr16:15151361 | RRN3 | chr16:15153881-15188158:- | 0.22 | 3.94 | 9.78E-5 | Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid);Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) |
| BLCA | cis | rs2280018 | 1 | rs2280018 | chr16:15150833 | RRN3 | chr16:15153881-15188158:- | -0.24 | -4.26 | 2.6E-5 | Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid);Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) |
| BLCA | cis | rs7061710 | 1 | rs2281006 | chr1:171110869 | FMO2 | chr1:171154388-171181822:+ | -0.24 | -4.38 | 1.53E-5 | Blood metabolite levels |
| BLCA | cis | rs7224737 | 1 | rs2285657 | chr17:40272594 | DHX58 | chr17:40253422-40264751:- | -0.25 | -4.59 | 5.98E-6 | Fibrinogen levels |
| BLCA | cis | rs2285947 | 1 | rs2285946 | chr7:21583329 | DNAH11 | chr7:21582833-21941455:+ | -0.3 | -4.97 | 9.88E-7 | Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) |
| BLCA | cis | rs2285947 | 1 | rs2285947 | chr7:21584088 | DNAH11 | chr7:21582833-21941455:+ | 0.28 | 4.76 | 2.79E-6 | Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) |
| BLCA | cis | rs2285947 | 1 | rs2285949 | chr7:21584243 | DNAH11 | chr7:21582833-21941455:+ | -0.3 | -4.98 | 9.83E-7 | Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) |